Probing the In Vitro Cytotoxicity of the Veterinary Drug Oxytetracycline

• DOI: 10.1371/journal.pone.0102334
• Publication Date: 2014-07-14T18:07:04Z
• Authors: Zhenxing Chi; Rutao Liu; Hong You; Shanshan Ma; Hao Cui; Qiang Zhang
• Keywords: Adenosine Triphosphatases; 0303 health sciences; Erythrocytes; Science; Q; R; Veterinary Drugs; Oxytetracycline; Hemolysis; Antioxidants; 03 medical and health sciences; Toxicity Tests; Medicine; Humans; Research Article

The study investigated the effect of oxytetracycline (OTC) on anti-oxidative defense system, structure (hemolysis rate and morphology) function (ATP enzyme activity) human red blood cells (hRBCs) to investigate possible toxic mechanism OTC hRBCs. experimental results indicate that can cause a decline in antioxidant system hRBCs, resulting oxidative stress. bring about morphological changes further leads hemolysis, when concentration is over 8×10−5 M (about 164 µg/ml). At low concentration, below 4×10−5 (82 µg/ml), enhance activity ATP known as hormesis. However, at high above 82 enzymatic was inhibited, affecting estalished toxicity hRBCs facilitate deeper understanding vivo.