Serum 25-Hydroxyvitamin D and Insulin Resistance in Apparently Healthy Adolescents

• DOI: 10.1371/journal.pone.0103108
• Publication Date: 2014-07-29T17:46:05Z
• Authors: Dong Phil Choi; Sun Min Oh; Ju-Mi Lee; Hye Min Cho; Won Joon Lee; Bo-Mi Song; Yumie Rhee; Hyeon Chang Kim
• Keywords: Quartile

Purpose Vitamin D deficiency is a common condition that associated with diabetes and insulin resistance. However, the association between vitamin resistance has not been fully studied, especially in general adolescent population. Therefore, we assessed serum 25-hydroxyvitamin [25(OH)D] level among apparently healthy Korean adolescents. Methods A total of 260 (135 male 125 female) adolescents rural high school were for 25(OH)D, fasting plasma glucose, insulin. All participants aged 15 to 16 years old, without known hypertension or diabetes. Serum 25(OH)D was analyzed both as continuous categorical variable Insulin estimated by homeostasis model assessment (HOMA-IR). Increased operationally defined HOMA-IR value higher than sex-specific 75th percentile. Results In adolescents, every 10 ng/ml decrease 0.25 unit increase (p = 0.003) after adjusting age BMI. Compared those highest quartile, lowest quartile at significantly risk resistance: unadjusted odds ratio 4.06 (95% CI, 1.26 13.07); BMI adjusted 3.59 1.03 12.57). level, either measure, female Conclusions This study suggests may be inversely