Effect of Atomoxetine on Hyperactivity in an Animal Model of Attention-Deficit/Hyperactivity Disorder (ADHD)

• DOI: 10.1371/journal.pone.0108918
• Publication Date: 2014-10-01T17:59:43Z
• Authors: Su Jin Moon; Chang Ju Kim; Yeon Jung Lee; Minha Hong; Juhee Han; Geon Ho Bahn
• Keywords: Atomoxetine hydrochloride

Hyperactivity related behaviors as well inattention and impulsivity are regarded the nuclear symptoms of attention-deficit/hyperactivity disorder (ADHD).To investigate therapeutic effects atomoxetine on motor activity in relation to expression dopamine (DA) D2 receptor based hypothesis that DA system hypofunction causes ADHD symptoms, which would correlate with extensive overproduction a lack synthesis specific brain regions: prefrontal cortex (PFC), striatum, hypothalamus.Young male spontaneously hypertensive rats (SHR), animal models ADHD, were randomly divided into four groups according daily dosage treated for 21 consecutive days. The animals assessed using an open-field test, was examined.The improved continuously group at dose 1 mg/Kg/day than 0.25 or 0.5 mg/Kg/day. With respect immunohistochemistry, we observed significantly increased PFC, hypothalamus SHRs compared WKY rats. Treatment decreased SHRs, dose-dependent manner.Hyperactivity young can be by treatment via pathway.