Epicardial Adipose Tissue Thickness Correlates with the Presence and Severity of Angiographic Coronary Artery Disease in Stable Patients with Chest Pain

• DOI: 10.1371/journal.pone.0110005
• Publication Date: 2014-10-21T18:03:13Z
• Authors: Fabien A. Picard; Pascal Gueret; Jean-Pierre Laissy; Stéphane Champagne; Florence Leclercq; Didier Carrié; Jean-Michel Juliard; Patrick Henry; Ralph Niarra; Gilles Chatellier; Philippe Gabriel ...
• Keywords: Coronary arteries

Objective Epicardial adipose tissue (EAT) is suggested to correlate with metabolic risk factors and promote plaque development in the coronary arteries. We sought determine whether EAT thickness was associated or not presence extent of angiographic artery disease (CAD). Methods measured epicardial fat by computed tomography assessed CAD angiography participants from prospective EVASCAN study. The association cardiovascular factors, calcification scoring using multivariate regression analysis. Results Of 970 patients (age 60.9 years, 71% male), 75% (n = 731) had CAD. Patients thicker on left ventricle lateral wall when compared without (2.74±2.4 mm vs. 2.08±2.1 mm; p 0.0001). adjusted odds ratio (OR) for a patient LVLW value ≥2.8 have OR 1.46 [1.03–2.08], 0.0326 after adjusting factors. also correlated number diseased vessels (p 0.0001 trend). By receiver operating characteristic curve analysis, an best predicted of>50% diameter stenosis, sensitivity specificity 46.1% 66.5% respectively (AUC:0.58). Coronary calcium AUC 0.76. Conclusion Although CAD, it has low performance diagnosis