Cerebrospinal Fluid Levels of Amyloid Precursor Protein Are Associated with Ventricular Size in Post-Hemorrhagic Hydrocephalus of Prematurity

• DOI: 10.1371/journal.pone.0115045
• Publication Date: 2015-03-04T19:08:47Z
• Authors: Diego M. Morales; Richard Holubkov; Terri E. Inder; Haejun C. Ahn; Deanna Mercer; Rakesh Rao; James P. McAllister; David M. Holtzman; David D. Limbrick
• Keywords: Male; Science; Q; R; Infant, Newborn; Neural Cell Adhesion Molecule L1; Organ Size; CD56 Antigen; Cerebral Ventricles; 3. Good health; Amyloid beta-Protein Precursor; 03 medical and health sciences; 0302 clinical medicine; Medicine; Humans; Premature Birth; Female; Biomarkers; Research Article; Hydrocephalus; Ultrasonography

Background Neurological outcomes of preterm infants with post-hemorrhagic hydrocephalus (PHH) remain among the worst in infancy, yet there few instruments to inform treatment PHH. We previously observed PHH-associated elevations cerebrospinal fluid (CSF) amyloid precursor protein (APP), neural cell adhesion molecule-L1 (L1CAM), molecule-1 (NCAM-1), and other mediators neurodevelopment. Objective The objective this study was examine association CSF APP, L1CAM, NCAM-1 ventricular size as an early step toward developing markers Methods levels NCAM-1, total (TP) were measured 12 undergoing PHH treatment. Ventricular determined using cranial ultrasounds. relationships between occipitofrontal circumference (OFC), volume removed, examined correlation regression analyses. Results but not TP paralleled treatment-related changes size. APP demonstrated strongest size, estimated by frontal-occipital horn ratio (FOR) (Pearson R = 0.76, p 0.004), followed (R 0.66, 0.02) L1CAM 0.57,p 0.055). correlated FOR 0.02, 0.95). Conclusions Herein, we report novel observation that shows a robust treated for results from suggest related proteins at once hold promise biomarkers provide insight into neurological consequences infant.