Abnormal Pulmonary Function and Respiratory Muscle Strength Findings in Chinese Patients with Parkinson’s Disease and Multiple System Atrophy–Comparison with Normal Elderly

• DOI: 10.1371/journal.pone.0116123
• Publication Date: 2014-12-29T18:58:03Z
• Authors: Yao Wang; Wei-bo Shao; Li Gao; Jie Lu; Hao Gu; Li-hua Sun; Yan Tan; Ying-dong Zhang
• Keywords: Vital capacity; Muscle Atrophy

Background There have been limited comparative data regarding the investigations on pulmonary and respiratory muscle function in patients with different parkinsonism disorders such as Parkinson’s disease (PD) multiple system atrophy (MSA) versus normal elderly. The present study is aiming to characterize performance of strength PD MSA, investigate association severity motor symptoms duration. Methods Pulmonary tests were performed 30 PD, 27 MSA well 20 age-, sex-, height-, weight-matched elderly controls. All underwent United rating scale (UPDRS) or united (UMSARS) separately diagnosed. Results Vital capacity, forced expiratory volume 1 second vital capacity decreased, residual ratio total lung increased both groups compared controls (p<0.05). Diffusing was decreased group, control Respiratory lower than values representing spirometry found a negative linear correlation mean score UPDRS-III UMSARS-I MSA. showed UMSARS-II duration patients. Conclusions These findings suggest that dysfunction involved remarkably reduced, some parameters correlate illness severity. compromised neurodegenerative should be focus further researches.