Arthritis Induces Early Bone High Turnover, Structural Degradation and Mechanical Weakness

• DOI: 10.1371/journal.pone.0117100
• Publication Date: 2015-01-24T19:12:07Z
• Authors: Bruno Vidal; Rita Cascão; Ana Catarina Vale; Inês Cavaleiro; Maria Fátima Vaz; José Américo Alme...; Helena Canhão; João Eurico Fonseca
• Keywords: Bone remodeling

Background We have previously found in the chronic SKG mouse model of arthritis that long standing (5 and 8 months) inflammation directly leads to high collagen bone turnover, disorganization network, disturbed microstructure degradation biomechanical properties. The main goal present work was study effects first days inflammatory process on microarchitecture mechanical properties bone. Methods Twenty eight Wistar adjuvant-induced (AIA) rats were monitored during 22 after disease induction for score, ankle perimeter body weight. Healthy non-arthritic used as controls compar-ison. After progression sacrificed samples collected histomorphometrical, energy dispersive X-ray spectroscopical analysis 3-point bending. Blood also turnover markers. Results AIA had an increased (as inferred from P1NP CTX1, p = 0.0010 0.0002, respectively) this paralleled by a decreased mineral content (calcium 0.0046 phos-phorus 0.0046). Histomorphometry showed lower trabecular thickness (p 0.0002) volume 0.0003) higher sepa-ration 0.0009) arthritic group compared with controls. In addition, tests evidence fragility depicted diminished values yield stress ultimate fracture point 0.0061 0.0279, re-spectively) group. Conclusions shown rat induc-es early structural degradation, loss weak-ness.