Progressive Rise in Red Blood Cell Distribution Width Predicts Mortality and Cardiovascular Events in End-Stage Renal Disease Patients

• DOI: 10.1371/journal.pone.0126272
• Publication Date: 2015-05-11T17:54:48Z
• Authors: Hye Eun Yoon; Sung Jun Kim; Hyeon Seok Hwang; Sungjin Chung; Chul Woo Yang; Seok Joon Shin
• Keywords: Adult; Male; Erythrocytes; Science; Q; R; Kaplan-Meier Estimate; Middle Aged; Disease-Free Survival; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Cardiovascular Diseases; Multivariate Analysis; Linear Models; Medicine; Humans; Kidney Failure, Chronic; Female; Research Article; Aged; Retrospective Studies

Red blood cell distribution width (RDW) is a robust marker of adverse clinical outcomes in various populations. However, the significance progressive rise RDW undetermined end-stage renal disease (ESRD) patients. The purpose this study was to determine prognostic importance change ESRD Three hundred twenty-six incident dialysis patients were retrospectively analyzed. Temporal changes during 12 months after initiation assessed by calculating coefficients linear regression. Patients divided into two groups: an RDW-decreased group who had negative coefficient values (n = 177) and RDW-increased positive 149). associations between rising mortality cardiovascular (CV) events investigated. During median follow-up 2.7 years (range, 1.0–7.7 years), 75 deaths (24.0%) 60 non-fatal CV (18.4%) occurred. event-free survival rate for composite end-points lower (P 0.004). After categorizing according baseline RDW, lowest with >14.9% increased highest ≤14.9% decreased 0.02). In multivariate analysis, independently associated (hazard ratio 1.75, P 0.007), whereas not. This shows that predicted Rising could be additive predictor