Dietary Intake of Sulforaphane-Rich Broccoli Sprout Extracts during Juvenile and Adolescence Can Prevent Phencyclidine-Induced Cognitive Deficits at Adulthood

• DOI: 10.1371/journal.pone.0127244
• Publication Date: 2015-06-24T14:14:32Z
• Authors: Yumi Shirai; Yuko Fujita; Ryota Hashimoto; Kazutaka Ohi; Hidenaga Yamamori; Yuka Yasuda; Tamaki Ishima; Hiroyuki Suganuma; Yusuke Ushida; Masatoshi Takeda; Kenji Hashimoto
• Keywords: Sulforaphane; Phencyclidine; Cognitive deficit

Oxidative stress and inflammation play a role in cognitive impairment, which is core symptom of schizophrenia. Furthermore, hallmark the pathophysiology this disease dysfunction cortical inhibitory γ-aminobutyric acid (GABA) neurons expressing parvalbumin (PV), also involved impairment. Sulforaphane (SFN), an isothiocyanate derived from broccoli, potent activator transcription factor Nrf2, plays central inducible expressions many cytoprotective genes response to oxidative stress. Keap1 cytoplasmic protein that essential for regulation Nrf2 activity. Here, we found pretreatment with SFN attenuated deficits, increase 8-oxo-dG-positive cells, decrease PV-positive cells medial prefrontal cortex hippocampus after repeated administration phencyclidine (PCP). PCP-induced deficits were improved by subsequent subchronic SFN. Interestingly, dietary intake glucoraphanin (a glucosinolate precursor SFN) during juvenile adolescence prevented onset as well brain at adulthood. Moreover, NRF2 gene KEAP1 had epistatic effect on impairment (e.g., working memory processing speed) patients These findings suggest may have prophylactic therapeutic effects Therefore, SFN-rich broccoli sprouts prevent psychosis