A Seven-microRNA Expression Signature Predicts Survival in Hepatocellular Carcinoma

• DOI: 10.1371/journal.pone.0128628
• Publication Date: 2015-06-05T15:04:01Z
• Authors: Jian Zhang; Charing C. N. Chong; George G. Chen; Paul B. S. Lai
• Keywords: KEGG; Liver Cancer

Hepatocellular carcinoma (HCC) is the fifth common cancer. The differential expression of microRNAs (miRNAs) has been associated with prognosis various cancers. However, limited information available regarding genome-wide miRNA profiles in HCC to generate a tumor-specific signature prognostic values. In this study, 327 patients, including tumor and 43 adjacent non-tumor tissues, from Cancer Genome Atlas (TCGA) Liver hepatocellular (LIHC) were analyzed. associations differentially expressed miRNAs patient survival other clinical characteristics examined t-test Cox proportional regression model. Finally, was generated Kaplan–Meier survival, univariate\multivariate analyses KEGG pathway analysis. Results showed that total 207 found between tissues. 78 them also discriminatively gender, race, grade AJCC stage. Seven significantly (P value <0.001). Among seven significant miRNAs, six (hsa-mir-326, hsa-mir-3677, hsa-mir-511-1, hsa-mir-511-2, hsa-mir-9-1, hsa-mir-9-2) negatively overall (OS), while remaining one (hsa-mir-30d) positively correlated. A 7-miRNAs validated as an independent predictor. Collectively, we have identified model based on which can be used assess patients' survival. Additional work needed translate our into practice.