Assessing the Influence of Different Comorbidities Indexes on the Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation in a Developing Country

• DOI: 10.1371/journal.pone.0137390
• Publication Date: 2015-09-22T14:11:12Z
• Authors: Gustavo Machado T...; Henrique Bittencourt; Antonio Vaz de Ma...; Glaucia Helena Ma...; Enrico Antônio Co...; Suely Meireles Re...
• Keywords: Cumulative incidence

Although the application of Hematopoietic Cell Transplantation-specific Comorbidity Index (HCT-CI) has enabled better prediction transplant-related mortality (TRM) in allogeneic hematopoietic stem cell transplants (AHSCT), data from developing countries are scarce. This study prospectively evaluated HCT-CI and Adult Evaluation (ACE-27), its original a modified version, as predictors post-transplant complications adults undergoing first related or unrelated AHSCT Brazil. Both bone marrow (BM) peripheral blood cells (PBSC) graft sources were included. We analyzed cumulative incidence granulocyte platelet recovery, sinusoidal obstructive syndrome, acute chronic graft-versus-host disease, relapse mortality, rates event-free survival overall survival. Ninety-nine patients assessed. Median age was 38 years (18-65 years); ≥ 3 accounted for only 8% cases; hematologic malignancies comprised 75.8% indications AHSCT. There no association between ACE-27 with TRM any other studied outcomes after These results show that, population studied, none comorbidity indexes seem to be associated outcomes. A significantly low frequency high-risk (HCT-CI 3) this Brazilian might justify these results.