Low Prognostic Nutritional Index Correlates with Worse Survival in Patients with Advanced NSCLC following EGFR-TKIs

• DOI: 10.1371/journal.pone.0147226
• Publication Date: 2016-01-19T15:39:52Z
• Authors: Jin Sheng; Yun-Peng Yang; Yu-Xiang Ma; Tao Qin; Zhi-Huang Hu; Shao-Dong Hong; Ting Zhou; Yan Huang; Hong-Yun Zhao; Li Zhang
• Keywords: Univariate analysis

Objective This study was designed to demonstrate the prognostic value of nutritional index (PNI), a reflection systemic immunonutritional status, on long-term survival patients taking epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs). Methods In this retrospective study, eligible advanced NSCLC with sensitive EGFR mutations (exon 19 deletion or L858R in exon 21) were included investigate correlation between PNI and overall (OS). The calculated as 10 x serum albumin (g/dl) + 0.005 peripheral lymphocyte count (per mm3). significance other clinicopathologic factors identified by univariate multivariate analysis. Results Finally, 144 met inclusion criteria. optimal cut-off for stratification 48.78. Compared high group (n = 81), low 63) significantly associated elevated C-reactive protein (CRP) level non-response TKIs. Overall superior (HR, 0.44, p 0.004), especially patient 0.37, 0.009) rather than 0.69, 0.401). independent validated Conclusion pilot investigation demonstrated that correlates worse EGFR-TKIs. assessment convenient index, known PNI, worth attention routine clinical practice following EGFR-TKIs treatment.