UCP1 and UCP3 Expression Is Associated with Lipid and Carbohydrate Oxidation and Body Composition

• DOI: 10.1371/journal.pone.0150811
• Publication Date: 2016-03-09T18:46:59Z
• Authors: Bruno A. P. Oliveira; Marcela A. S. Pinhel; Carolina F. Nicol...; Cristiana C. Oliv...; Driele C. G. Quin...; Natália Y. Noronha; Júlio S. Marchini; Ana J. Marchry; Wilson S. Junior; Carla B. Nonino
• Keywords: UCP3; Thermogenin; Bioelectrical Impedance Analysis; Lipid Oxidation

Background/Objective Uncoupling proteins (UCPs) are located in the inner membrane of mitochondria. These participate thermogenesis and energy expenditure. This study aimed to evaluate how UCP1 UCP3 expression influences substrate oxidation elicits possible changes body composition patients submitted bariatric surgery. Subjects/Methods is a longitudinal comprising 13 women with obesity grade III that underwent surgery 10 healthy weight individuals (control group). Body was assessed by bioelectrical impedance. Carbohydrate fat determined indirect calorimetry. Subcutaneous adipose tissue collected for gene analysis. QPCR used expression. Results Obese control group differed significantly terms lipid carbohydrate oxidation. Six months after surgery, differences disappeared. Lipid correlated percentage mass postoperative period. Multiple linear regression analysis showed genes contributed Additionally, associated BMI, lean mass, Conclusions In addition, participates modulation six postoperatively.