A Comparison of Biocompatibility of a Titanium Alloy Fabricated by Electron Beam Melting and Selective Laser Melting

• DOI: 10.1371/journal.pone.0158513
• Publication Date: 2016-07-08T18:38:20Z
• Authors: Hong Wang; Bingjing Zhao; Changkui Liu; Chao Wang; Xinying Tan; Min Hu
• Keywords: Selective Laser Melting; Biocompatibility; Titanium alloy; Biological safety

Electron beam melting (EBM) and selective laser (SLM) are two advanced rapid prototyping manufacturing technologies capable of fabricating complex structures geometric shapes from metallic materials using computer tomography (CT) Computer-aided Design (CAD) data. Compared to traditional used for products, EBM SLM alter the mechanical, physical chemical properties, which closely related biocompatibility products. In this study, we evaluate compare biocompatibility, including cytocompatibility, haemocompatibility, skin irritation sensitivity Ti6Al4V fabricated by SLM. The results were analysed one-way ANOVA Tukey's multiple comparison test. Both exhibited good cytobiocompatibility. haemolytic ratios 2.24% 2.46%, respectively, demonstrated haemocompatibility. samples showed no dermal when exposed rabbits. a delayed hypersensitivity test, allergic reaction or was observed in guinea pigs. Based on these results, cytobiocompatible, haemocompatible, non-irritant non-sensitizing materials. Although data cell adhesion, proliferation, ALP activity ratio higher group, there significant differences between different methods.