To Assess the Association between Glucose Metabolism and Ectopic Lipid Content in Different Clinical Classifications of PCOS

• DOI: 10.1371/journal.pone.0160571
• Publication Date: 2016-08-09T17:35:50Z
• Authors: Christian S. Göbl; Johannes Ott; Latife Bozkurt; Michael Feichtinger; Victoria Rehmann; Anna Cserjan; Maike Heinisch; Helmut Steinbrecher; Ivica JustKukurova; Radka Tuskova; Michael Leutner; Elisabeth Vytiska...; Christine Kurz; Andrea Weghofer; Andrea Tura; Christian Egarter; Alexandra Kautzky...
• Keywords: Hyperinsulinemia; Hyperandrogenism; Dyslipidemia; Carbohydrate Metabolism; Steatosis

There are emerging data indicating an association between PCOS (polycystic ovary syndrome) and metabolic derangements with potential impact on its clinical presentation. This study aims to evaluate the pathophysiological processes beyond particular focus carbohydrate metabolism, ectopic lipids their possible interaction. Differences two established classifications of disease should be additionally evaluated.A characterization was performed in 53 untreated patients as well 20 controls including extended oral glucose tolerance test (OGTT, assess insulin sensitivity, secretion ß-cell function) addition a detailed examination lipid content muscle liver by nuclear magnetic resonance spectroscopy.Women classified original NIH 1990 definition showed more adverse risk profile compared women characterized additional Rotterdam 2003 phenotypes. Subtle were observed both subgroups, altered shapes OGTT curves, impaired action hyperinsulinemia due increased attenuated hepatic extraction. No differences for groups. However, particularly hepatocellular significantly related parameters like whole body dyslipidemia free androgen index.Subtle alterations metabolism present classifications, but profound subjects meeting criteria. Females did not differ lipids, however, fat tightly hyperandrogenism profile.