Neuronal Splicing Regulator RBFOX3 (NeuN) Regulates Adult Hippocampal Neurogenesis and Synaptogenesis

• DOI: 10.1371/journal.pone.0164164
• Publication Date: 2016-10-04T13:45:51Z
• Authors: Yi-Sian Lin; Han-Ying Wang; De-Fong Huang; Pei-Fen Hsieh; Meng-Ying Lin; Chih-Hsuan Chou; I-Ju Wu; Guo-Jen Huang; Susan Shur-Fen Gau; Hsien-Sung Huang
• Keywords: Synaptogenesis; Knockout mouse; Doublecortin; NeuN

Dysfunction of RBFOX3 has been identified in neurodevelopmental disorders such as autism spectrum disorder, cognitive impairments and epilepsy a causal relationship with these diseases previously demonstrated Rbfox3 homozygous knockout mice. Despite the importance during neurodevelopment, function regarding neurogenesis synaptogenesis remains unclear. To address this critical question, we profiled developmental expression pattern brain wild-type mice analyzed volume, disease-relevant behaviors, neurogenesis, synaptic plasticity, their corresponding counterparts. Here report that differs developmentally for distinct regions. Moreover, exhibited cold hyperalgesia impaired abilities. Focusing on hippocampal phenotypes, found displayed deficits which was correlated impairments. Furthermore, regulates exons genes synapse-related function. Synaptic plasticity density, are related to were altered dentate gyrus mice; decreased density synapses increased. Taken together, our results demonstrate important role neural development maturation. In addition, abnormalities structure occur Our findings may offer mechanistic explanations human associated dysfunctional RBFOX3.