Effects of High-Intensity Training of Professional Runners on Myocardial Hypertrophy and Subclinical Atherosclerosis

• DOI: 10.1371/journal.pone.0166009
• Publication Date: 2016-11-11T13:40:59Z
• Authors: Célia Regina de O...; Maria Cristina de...; Valdir Lauro Schwerz; Rui Manuel dos Sa...; Henrique Andrade ...; Marília Izar Helf...; Henrique Tria Bianco; Carolina Nunes Fr...; Carlos Eduardo do...; Francisco Antonio...
• Keywords: Subclinical infection

To evaluate the effects of long-term exposure to high-intensity training among professional runners on cardiac hypertrophy and subclinical atherosclerosis. Prospective study included both sexes (n = 52) age gender matched controls 57), without classical cardiovascular risk factors. Ventricular was quantified by echocardiography linear method carotid intima-media thickness (cIMT) 2-D images obtained ultrasonography. Endothelial function evaluated flow-mediated dilation (FMD). Steroid hormones were HPLC followed LC-MS/MS. Higher left ventricular (LV) mass index found in male athletes (p<0.0001 vs. other groups). When adjusted for gender, degree classified as mildly, moderately or severely abnormal 26%, 35%, 30%, respectively, female athletes, 39%, 14%, 21%, athletes. ratio early (E) late (A) filling velocities genders. Male presented lower cIMT right (p 0.012 controls) common arteries, differences between controls. FMD results similar groups. serum testosterone levels groups) they correlated with LV (r 0.50, p<0.0001). The chronic genders associated increased adaptive remodeling. Less atherosclerosis Differences steroid may account part these findings.