Genome Analysis of Streptococcus pyogenes Associated with Pharyngitis and Skin Infections

• DOI: 10.1371/journal.pone.0168177
• Publication Date: 2016-12-15T18:57:35Z
• Authors: Joe Ibrahim; Jonathan A. Eisen; Guillaume Jospin; David A. Coil; Georges Khazen; Sima Tokajian
• Keywords: Streptococcus Pyogenes; Prophage; Toxic shock syndrome; Lineage (genetic)

Streptococcus pyogenes is a very important human pathogen, commonly associated with skin or throat infections but can also cause life-threatening situations including sepsis, streptococcal toxic shock syndrome, and necrotizing fasciitis. Various studies involving typing molecular characterization of S. have been published to date; however next-generation sequencing (NGS) provide comprehensive collection an organism’s genetic variation. In this study, the genomes nine isolates pharyngitis infection were sequenced studied for presence virulence genes, resistance elements, prophages, genomic recombination, other features. Additionally, comparative phylogenetic analysis global clones highlighted their possible evolutionary lineage site infection. The found house multitude features gene regulation systems, factors antimicrobial mechanisms.