Factors Associated with the Retinal Nerve Fiber Layer Loss after Acute Primary Angle Closure: A Prospective EDI-OCT Study

• DOI: 10.1371/journal.pone.0168678
• Publication Date: 2017-01-31T18:36:40Z
• Authors: Eun Ji Lee; Tae-Woo Kim; Kyoung Min Lee; Seung Hyen Lee; Hyunjoong Kim
• Keywords: Lamina

To determine the factors associated with retinal nerve fiber layer (RNFL) loss in eyes acute primary angle-closure (APAC), particularly focusing on influence of change anterior lamina cribrosa surface depth (LCD).After initial presentation, 30 unilateral APAC were followed up at following specific time points over a 12-month period: 1 week, 1~2 months, 2~3 5~6 and 11~12 months. These follow-ups involved intraocular pressure measurements, enhanced depth-imaging spectral-domain optical coherence tomography (SD-OCT) scanning optic disc, measurements circumpapillary RNFL thickness. The prelaminar tissue thickness (PLT) LCD determined SD-OCT images obtained each follow-up visit.Repeated measures analysis variance revealed significant pattern decrease global thickness, PLT, (all p<0.001). decreased continuously throughout period, while PLT until months did not thereafter. reduced then also remained steady. Multivariable regression that symptoms longer duration before receiving laser peripheral iridotomy (LI) (p = 0.049) larger reduction 0.034) conversion to an abnormal defined using OCT normative data.Early short-term decreases overall long-term peripapillary observed during after episode. A LI treatment progressive loss. may indicate prior presence pressure-induced stress had been imposed head Glaucomatous progression should be suspected showing remission.