Gut dysbiosis is associated with metabolism and systemic inflammation in patients with ischemic stroke

• DOI: 10.1371/journal.pone.0171521
• Publication Date: 2017-02-06T19:01:04Z
• Authors: Kazuo Yamashiro; Ryota Tanaka; Takao Urabe; Yuji Ueno; Yuichiro Yamashiro; Koji Nomoto; Takuya Takahashi; Hirokazu Tsuji; Takashi Asahara; Nobutaka Hattori
• Keywords: Dysbiosis; Glycated hemoglobin; Stroke

The role of metabolic diseases in ischemic stroke has become a primary concern both research and clinical practice. Increasing evidence suggests that dysbiosis is associated with diseases. aim this study was to investigate whether the gut microbiota, as well concentrations organic acids, major products dietary fiber fermentation by are altered patients stroke, examine association between these changes host metabolism inflammation. We analyzed composition fecal microbiota acids 41 40 control subjects via 16S 23S rRNA-targeted quantitative reverse transcription (qRT)-PCR high-performance liquid chromatography analyses, respectively. Multivariable linear regression analysis subsequently performed evaluate relationships bacterial counts acid concentrations. Correlations bioclinical markers were also evaluated. Although only Lactobacillus ruminis significantly higher compared controls, multivariable showed independently increased Atopobium cluster ruminis, decreased numbers sakei subgroup, independent age, hypertension, type 2 diabetes. Changes prevalence positively correlated serum interleukin-6 levels. In addition, acetic valeric acid, Meanwhile, negatively levels glycated hemoglobin low-density lipoprotein cholesterol, whereas level high sensitivity C-reactive protein white blood cell counts. Together, our findings suggest