Stress increases the risk of type 2 diabetes onset in women: A 12-year longitudinal study using causal modelling

• DOI: 10.1371/journal.pone.0172126
• Publication Date: 2017-02-21T19:20:26Z
• Authors: Melissa L. Harris; Christopher Oldme...; Alexis Hure; Judy Luu; Deborah Loxton; John Attia
• Keywords: Longitudinal Study

Type 2 diabetes is associated with significant morbidity and mortality. Modifiable risk factors have been found to contribute up 60% of type risk. However, continues rise despite implementation interventions based on traditional factors. There a clear need identify additional for chronic disease prevention. The aim this study was examine the relationship between perceived stress onset, partition estimates into direct indirect effects.Women born in 1946-1951 (n = 12,844) completed surveys Australian Longitudinal Study Women's Health 1998, 2001, 2004, 2007 2010. total causal effect estimated using logistic regression marginal structural modelling. Controlled effects were through conditioning model. A graded association all mediators multivariate time lag analyses. hypertension, as well physical activity body mass index, diabetes, but not smoking or diet quality. Moderate/high levels 2.3-fold increase odds three years later, effect. Results only slightly attenuated when partitioned, explaining 10-20% excess variation diabetes.Perceived strong factor diabetes. majority estimate mediated by activity, smoking, quality, index. This gives new pathway prevention trials clinical practice.