Differentially expressed proteins underlying childhood cortical dysplasia with epilepsy identified by iTRAQ proteomic profiling

• DOI: 10.1371/journal.pone.0172214
• Publication Date: 2017-02-21T19:17:37Z
• Authors: Lu Qin; Xi Liu; Shiyong Liu; Yi Liu; Yixuan Yang; Hui Yang; Yangmei Chen; Lifen Chen
• Keywords: Pathogenesis

Cortical dysplasia accounts for at least 14% of epilepsy cases, and is mostly seen in children. However, the understanding molecular mechanisms pathogenesis underlying cortical limited. The aim this cross-sectional study to identify potential key molecules by screening proteins expressed brain tissues childhood patients with using isobaric tags relative absolute quantitation-based tandem mass spectrometry compared controls, several differentially that are not reported be associated previously were selected validation real-time polymerase chain reaction, immunoblotting immunohistochemistry. 153 out 3340 identified between controls. And FSCN1, CRMP1, NDRG1, DPYSL5, MAP4, FABP3 increased patients, while PRDX6 PSAP decreased. This first report on dysplasia. We differential expression FABP3, these involved various processes have function. These results may provide new directions or targets research dysplasia, helpful revealing and/or pathophysiology if further investigated.