The shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up study

• DOI: 10.1371/journal.pone.0174811
• Publication Date: 2017-04-06T19:16:59Z
• Authors: Fabiana Rodrigues...; Maria Eugênia Fer...; Fellype Carvalho ...; Rodrigo Oliveira ...; Valéria de Melo M...; Carlos Eduardo Ro...; Aluizio Barbosa C...
• Keywords: Bone remodeling; Bone disease

Parathyroidectomy (PTX) may cause low levels of PTH, leading to an excessive reduction bone turnover, which is associated with poor outcomes in dialysis patients, including vascular calcification (VC). We aimed prospectively investigate the impact PTX on remodeling and its potential consequence progression VC hemodialysis patients. In this prospective study, 19 patients severe secondary hyperparathyroidism (sHPT) were evaluated. All underwent laboratorial tests coronary tomography at baseline and, 6 12 months after PTX; biopsy was performed 12-month. At baseline, all had increased PTH up 2500 pg/mL high turnover disease their biopsies. Fourteen (74%) VC. During follow-up, there a significant decrease 12-month, 90% evolved disease. period hungry syndrome (first months), no change calcium score observed. However, significantly thereafter (12th month). There association between severity conclusion, shift from occurs parallel progression, contributing understanding complex pathophysiology involving mineral metabolism cardiovascular