vWF correlates with visceral and pericardial adipose tissue in patients with a recent stroke of suspected cardiogenic etiology

• DOI: 10.1371/journal.pone.0178508
• Publication Date: 2017-06-01T13:47:30Z
• Authors: Antti Tapani Muur...; Mikko Taina; Juha Onatsu; Miika Korhonen; Kari Pulkki; Pekka Jäkälä; Ritva Vanninen; Pirjo Mustonen
• Keywords: Stroke; Etiology

A chronically elevated level of von Willebrand factor (vWF) is a common finding in patients with cardiovascular diseases. Obesity well-recognized risk for thrombotic complications including ischemic stroke, and it has been linked increased plasma vWF. We evaluated whether levels vWF associate areas visceral (VAT), pericardial (PAT), subcutaneous adipose tissue (SAT) compartments acute/subacute stroke.A total 69 stroke suspected cardiogenic etiology were examined. The antigen (vWF-ag) was measured both the acute phase chronic three months after stroke. VAT and/or PAT assessed computed tomography. As expected, patients, vWF-ag significantly higher than national reference population phase. correlated amounts PAT, but not tissue.These results agree previous observations inflammation/prothrombotic tendency cerebrovascular disease. Future studies should seek to clarify role type pathophysiology