Population-based incidence, seasonality and serotype distribution of invasive salmonellosis among children in Nanoro, rural Burkina Faso

• DOI: 10.1371/journal.pone.0178577
• Publication Date: 2017-07-10T13:30:06Z
• Authors: Issa Guiraud; Annelies Post; Seydou Nakanabo D...; Palpouguini Lompo; Jessica Maltha; Kamala Thriemer; Christian Marc Ta...; Benedikt Ley; Karim Derra; Emmanuel Bottieau; Adama Kazienga; Céline Schurmans; Raffaella Ravinetto; Eli Rouamba; Johan Van Griensven; Sophie Bertrand; Halidou Tinto; Jan Jacobs
• Keywords: Salmonella enterica; Blood Culture

Bloodstream infections (BSI) caused by Salmonella Typhi and invasive non-Typhoidal (iNTS) frequently affect children living in rural sub-Saharan Africa but data about incidence serotype distribution are rare.The present study assessed the population-based of BSI severe malaria a Health Demographic Surveillance System area with seasonal transmission Nanoro, Burkina Faso.Children between 2 months-15 years old febrile illness were enrolled during one-year surveillance period (May 2013-May 2014). Thick blood films cultures sampled processed upon admission. Population-based incidences corrected for non-referral, health seeking behavior, non-inclusion culture sensitivity. Adjusted rates expressed per 100,000 person-years observations (PYO).Among < 5 old, iNTS, PYO 4,138 (95% Confidence Interval (CI): 3,740-4,572), 224 CI: 138-340) 2,866 2,538-3,233) respectively. Among those aged 5-15 years, corresponding 25 8-60), 273 203-355) 135 87-195) Most iNTS occurred peak rainy season parallel increase Plasmodium falciparum malaria; no clear pattern was observed. accounted 13.3% 55.8% all 118 episodes; 71.6% (48/67) isolates enterica serovar Typhimurium 25.4% (17/67) Enteritidis; there apparent geographical clustering.The findings from West-Africa confirm high latter falciparum-related pattern. It urges prioritization development implementation as well vaccines this setting.