Assessment of treatment response during chemoradiation therapy for pancreatic cancer based on quantitative radiomic analysis of daily CTs: An exploratory study

• DOI: 10.1371/journal.pone.0178961
• Publication Date: 2017-06-02T13:53:05Z
• Authors: Xiaojian Chen; Kiyoko Oshima; Diane Schott; Hui Wu; William Hall; Yingqiu Song; Yalan Tao; Dingjie Li; Cheng Zheng; Paul Knechtges; Beth Erickson; X. Allen Li
• Keywords: Kurtosis

In an effort for early assessment of treatment response, we investigate radiation induced changes in quantitative CT features tumor during the delivery chemoradiation therapy (CRT) pancreatic cancer.Diagnostic-quality data acquired daily routine CT-guided CRT using a CT-on-rails 20 head cancer patients were analyzed. On each CT, head, spinal cord and aorta delineated histograms number (CTN) these contours extracted. Eight histogram-based radiomic metrics including mean CTN (MCTN), peak position, volume, standard deviation (SD), skewness, kurtosis, energy entropy calculated fraction. Paired t-test was used to check significance change specific metric at time. GEE model test association between over time different pathology responses.In general, histogram (but not cord) changed delivery. Changes from 1st 26th fraction MCTN ranged -15.8 3.9 HU with average -4.7 (p<0.001). Meanwhile volume decreased, skewness increased (less skewed), kurtosis decreased peaked). The MCTN, became significant after two weeks treatment. Patient pathological response is associated SD, skewness. cases good tend have large reductions increases SD kurtosis.Significant features, such as observed course pancreas based on analysis CTs. These may be potentially stratification therapeutic intensification.