Prognostic role of noninvasive liver reserve markers in patients with hepatocellular carcinoma undergoing transarterial chemoembolization

• DOI: 10.1371/journal.pone.0180408
• Publication Date: 2017-07-03T17:37:11Z
• Authors: Shu-Yein Ho; Po-Hong Liu; Chia-Yang Hsu; Cheng-Yuan Hsia; Yun-Hsuan Lee; Rheun-Chuan Lee; Yi-Hsiang Huang; Fa-Yauh Lee; Ming-Chih Hou; Ya-Ju Tsai; Teh-Ia Huo
• Keywords: Male; Carcinoma, Hepatocellular; Science; Q; Liver Neoplasms; R; 610; Middle Aged; Prognosis; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Medicine; Humans; Female; Chemoembolization, Therapeutic; Research Article; Aged

Various noninvasive liver reserve markers were proposed to indicate the severity of damage. However, role and feasibility these predict prognosis patients with hepatocellular carcinoma (HCC) are unknown. We aimed identify prognostic 8 currently used hepatic in HCC undergoing transarterial chemoembolization (TACE).Between 2002 2013, a total 881 TACE prospectively identified retrospectively analyzed. The baseline characteristics, tumor status collected. Homogeneity corrected Akaike information criteria (AICc) compared between markers. Cox proportional hazards model was independent predictors survival.Significant differences survival distribution found for albumin-bilirubin (ALBI) grade, Child-Turcotte-Pugh (CTP) class, Lok index, fibrosis index based on 4 factors (FIB-4), Göteborg University cirrhosis (GUCI), discriminant (CDI) end-stage disease (MELD) score (all p values <0.05). Among markers, ALBI grade showed highest homogeneity lowest AICc value, indicating better performance. multivariate analysis confirmed that 2, ascites, serum alkaline phosphatase α-fetoprotein level, diameter, vascular invasion performance significant predictors. well correlated CTP MLED scores.Our data suggest among may serve as an objective feasible surrogate TACE.