Mother-to-child transmission of HIV in Kenya: A cross-sectional analysis of the national database over nine years

• DOI: 10.1371/journal.pone.0183860
• Publication Date: 2017-08-29T17:39:09Z
• Authors: Matilu Mwau; Priska Bwana; Lucy Kithinji; Francis Ogollah; Samuel Ochieng; Catherine Akinyi; Maureen Adhiambo; Fred Ogumbo; Martin Sirengo; Caroline Boeke
• Keywords: Cross-sectional study; National database

To describe factors associated with mother-to-child HIV transmission (MTCT) in Kenya and identify opportunities to increase testing/care coverage.Cross-sectional analysis of national early infant diagnosis (EID) database.365,841 Kenyan infants were tested for from January 2007-July 2015 results, demographics, treatment information entered into a database. risk assessed using multivariable logistic regression.11.1% positive 2007-2010 6.9% 2014-2015. Greater odds infection observed females (OR: 1.08; 95% CI:1.05-1.11), older children (18-24 months vs. 6 weeks-2 months: 4.26; CI:3.87-4.69), whose mothers received no PMTCT intervention (vs. HAART OR: 1.92; CI:1.79-2.06), receiving prophylaxis nevirapine weeks 2.76; CI:2.51-3.05), mixed breastfed exclusive breastfeeding 1.39; CI:1.30-1.49). In 2014-2015, 9.1% had who not on during pregnancy, 9.8% prophylaxis, 7.0% breastfed. Infants exposed all three risky practices seven-fold higher compared those recommended practices. The highest yield HIV-positive found through targeted testing symptomatic pediatric/outpatient departments (>15%); still, most infected identified programs.Despite impressive gains Kenya's program, some HIV-infected present late are benefitting best Efforts these enforce evidence-based practice should be scaled up. Infant expanded departments, given high yields portals.