Association between E/e´ ratio and fluid overload in patients with predialysis chronic kidney disease

• DOI: 10.1371/journal.pone.0184764
• Publication Date: 2017-09-13T13:35:40Z
• Authors: Jae-Seok Kim; Jae-Won Yang; Jin Sae Yoo; Seung Ok Choi; Byoung-Geun Han
• Keywords: Heart Failure, Diastolic; Science; Q; R; Blood Pressure; Peptide Fragments; 3. Good health; Ventricular Dysfunction, Left; 03 medical and health sciences; 0302 clinical medicine; Echocardiography; Dielectric Spectroscopy; Natriuretic Peptide, Brain; Linear Models; Medicine; Humans; Renal Insufficiency, Chronic; Research Article; Retrospective Studies

Background Chronic fluid overload is common in patients with chronic kidney disease (CKD) and can time lead to diastolic dysfunction heart failure. We investigated whether markers of status, such as NT-proBNP bioimpedance spectroscopy (BIS), predict echocardiographic findings non-dialysis CKD5 patients. Methods BIS, echocardiography, measurement serum were performed CKD stage 5 at a single study visit. E/e´ ratio reflect mean LV pressure greater than 15 was used definition dysfunction. Results Eighty-four analyzed. Forty-six (54.76%) had ≤15 38 (45.24%) > (diastolic dysfunction). Patients E/e´>15 significantly higher (14,650 pg/mL) E/e´≤15 (4,271 more overhydration (OH), 5.1 liters compared 2.4 liters. The cut-off values predicting found be 2,797 pg/mL for 2.45 OH. Conclusions Regular monitoring status by BIS find patient risk developing Treatments correct may reduce the improve cardiovascular outcome CKD.