Advanced glycation end products dietary restriction effects on bacterial gut microbiota in peritoneal dialysis patients; a randomized open label controlled trial

• DOI: 10.1371/journal.pone.0184789
• Publication Date: 2017-09-20T13:31:09Z
• Authors: Rabi Yacoub; Melinda Nugent; Weijin Cai; Girish N. Nadkarni; Lee D. Chaves; Sham Abyad; Amanda M. Honan; Shruthi A. Thomas; Wei Zheng; Sujith A. Valiyap...; Mark A. Bryniarski; Yijun Sun; Michael Buck; Robert J. Genco; Richard J. Quigg; John C. He; Jaime Uribarri
• Keywords: Prevotella

The modern Western diet is rich in advanced glycation end products (AGEs). We have previously shown an association between dietary AGEs and markers of inflammation oxidative stress a population stage renal disease (ESRD) patients undergoing peritoneal dialysis (PD). In the current pilot study we explored effects on gut bacterial microbiota composition similar patients. play important role development progression cardiovascular (CVD) disease. Plasma concentrations different been to predict risk incident major adverse CVD events independently traditional factors, experimental animal models indicates possible might population. this randomized open label controlled trial, twenty PD habitually consuming high AGE were recruited into either continuing same (HAGE, n = 10) or one-month restriction (LAGE, 10). Blood stool samples collected at baseline after intervention. Variable regions V3-V4 16s rDNA sequenced taxa was identified phyla, genus, species levels. Dietary resulted significant decrease serum Nε-(carboxymethyl) lysine (CML) methylglyoxal-derivatives (MG). At baseline, our total cohort exhibited lower relative abundance Bacteroides Alistipes genus higher Prevotella when compared published data healthy altered with reduction copri Bifidobacterium animalis increased indistinctus, Clostridium citroniae, hathewayi, Ruminococcus gauvreauii abundance. show differences patients' population, as well microbiota, which warrants further studies.