Time frequency analysis of olfactory induced EEG-power change

• DOI: 10.1371/journal.pone.0185596
• Publication Date: 2017-10-10T17:28:22Z
• Authors: Valentin Alexande...; Pengfei Han; Stefanie Weise; Franziska Hösel; Robert Pellegrino; Thomas Hummel
• Keywords: Olfactometer; Stimulus (psychology)

Objectives The objective of the present study was to investigate usefulness time-frequency analysis (TFA) olfactory-induced EEG change with a low-cost, portable olfactometer in clinical investigation smell function. Materials & methods A total 78 volunteers participated. composed three parts where olfactory stimuli were presented using custom-built olfactometer. Part I designed optimize stimulus as well recording conditions. In part II EEG-power changes after olfactory/trigeminal stimulation compared between healthy participants and patients impairment. III test-retest reliability method evaluated subjects. Results indicated that most effective paradigm for presentation cued stimulus, an interstimulus interval 18-20s at duration 1000ms each quality 60 times blocks 20 each. we found central processing analyzed by TFA differed significantly controls even when controlling age. It possible reliably distinguish impairment from individuals high degree accuracy (healthy vs anosmic patients: sensitivity 75%; specificity 89%). addition could show good chemosensory induced III. Conclusions Central distinguishes accuracy. Importantly this can be achieved simple