Plasma microRNA profiling: Exploring better biomarkers for lymphoma surveillance

• DOI: 10.1371/journal.pone.0187722
• Publication Date: 2017-11-13T18:38:19Z
• Authors: Drirh Khare; Neta Goldschmidt; Aya Bardugo; Devorah Gur-Wahnon; Iddo Z. Ben-Dov; Batia Avni
• Keywords: Adult; Aged, 80 and over; Male; 0301 basic medicine; Science; Q; R; Middle Aged; Hodgkin Disease; 3. Good health; MicroRNAs; 03 medical and health sciences; Case-Control Studies; Biomarkers, Tumor; Medicine; Humans; Female; Lymphoma, Large B-Cell, Diffuse; Research Article; Aged

Early detection of relapsed lymphoma improves response and survival. Current tools lack power for early relapse, while being cumbersome expensive. We searched sensitive biomarkers that precede clinical serve further studies on therapy relapse. recruited 20 healthy adults, 14 diffuse large B-cell (DLBCL) patients 11 Hodgkin (HL) at diagnosis. Using small-RNA sequencing we identified in DLBCL increased plasma levels miR-124 miR-532-5p, decreased miR-425, miR-141, miR-145, miR-197, miR-345, miR-424, miR-128 miR-122. In the HL group, miR-25, miR-30a/d, miR-26b, miR-182, miR-186, miR-140* miR-125a to be up-regulated, miR-23a, miR-122, miR-93 miR-144 were down-regulated. Pathway analysis potential mRNAs targets these miRNA revealed group up-regulation STAT3, IL8, p13k/AKT TGF-B signaling, down-regulation PTEN p53 pathways; have found cAMP-mediated pathway potentially Survival analyses miR-20a/b, miR-106a/b associated with higher mortality. conclusion, sets dysregulated circulating might as reliable lymphoma.