The effect of low and high-intensity cycling in diesel exhaust on flow-mediated dilation, circulating NOx, endothelin-1 and blood pressure

• DOI: 10.1371/journal.pone.0192419
• Publication Date: 2018-02-23T10:55:16Z
• Authors: Luisa V. Giles; Scott J. Tebbutt; Christopher Carlsten; Michael S. Koehle
• Keywords: Intensity

Introduction Exposure to air pollution impairs aspects of endothelial function such as flow-mediated dilation (FMD). Outdoor exercisers are frequently exposed pollution, but how exercising in affects and these effects modified by exercise intensity poorly understood. Objectives Therefore, the purpose this study was determine low-intensity high-intensity cycling with diesel exhaust (DE) exposure on FMD, blood pressure, plasma nitrite nitrate (NOx) endothelin-1. Methods Eighteen males performed 30-minute trials low or (30% 60% power at VO2peak) a resting control condition. For each subject, trial once while breathing filtered (FA) DE (300ug/m3 PM2.5, six total). Preceding exposure, immediately post-exposure, 1 hour 2 hours pressure endothelin-1 NOx concentrations were measured. Data analyzed using repeated-measures ANOVA linear mixed model. Results Following DE, significantly increased greater than FA (p<0.05). Two following less (p = 0.037) did not modify response. affect FMD pressure. Conclusion Our results suggest that adversely NOX, endothelin-1, recommendations for healthy individuals moderate avoid during bouts high appear have no acute protective effect.