A novel Triclosan Methacrylate-based composite reduces the virulence of Streptococcus mutans biofilm

• DOI: 10.1371/journal.pone.0195244
• Publication Date: 2018-04-02T13:33:26Z
• Authors: Isaac Jordão de S...; Andréia Bolzan de...; Roberta Caroline ...; Jesus Roberto Tap...; Lúcia Helena Inno...; Rafael Nóbrega Stipp; Regina Maria Pupp...
• Keywords: Microscopy, Confocal; Virulence; Science; Q; R; Gene Expression Regulation, Bacterial; Anti-Bacterial Agents; Polyethylene Glycols; Streptococcus mutans; 03 medical and health sciences; 0302 clinical medicine; Bacterial Proteins; Polymethacrylic Acids; Biofilms; Medicine; Research Article

The use of antimicrobial monomers, linked to the polymer chain resin composites, is an interesting approach circumvent effects bacteria on dental and material surfaces. In addition, it can likely reduce incidence recurrent caries lesions. aim this study was evaluate a novel Triclosan Methacrylate (TM) monomer, which developed incorporated into experimental composite, Streptococcus mutans (S. mutans) biofilms, focusing analyses vicR, gtfD, gtfC, covR, gbpB gene expression, cell viability biofilm characteristics. contact time between TM-composite S. down-regulated covR up-regulated gtfC reduced significantly decreased parameters structure characteristics virulence. presence monomer causes harmful at molecular cellular levels in mutans, implying reduction virulence those microorganisms.