Physiochemical characterization and cytotoxicity evaluation of mercury-based formulation for the development of anticancer therapeuticals

• DOI: 10.1371/journal.pone.0195800
• Publication Date: 2018-04-18T17:51:36Z
• Authors: Kannan N; Shanmuga Sundar S; Balaji S; Arul Amuthan; Anil Kumar NV; Balasubramanian N
• Keywords: Developmental toxicity; MTT assay; HEK 293 cells; In vitro toxicology

The present study is aimed to evaluate the physiochemical properties and cytotoxicity of mercury-based formulation for development anticancer therapeuticals.The elemental morphological features were characterized by FE-SEM, XPS EDS. described was evaluated its on Hek293 MCF7 cell lines using MTT assay in vitro effects. vivo developmental toxicity also studied zebrafish embryos lethal concentration (LC50) values calculated as per OECD regulations.The characterizations confirmed presence mercuric compounds. particles spherical stable with size ranges between 20 80nm. Although PK contains mercurials it very effective only cancerous cells (MCF-7) less toxic normal (HEK 293). assessment embryo safer dosage 100μg/ml. However, a higher 1mg/ml led malformation such pericardial, tail yolk sac edema.The characterization HgS. results both studies showed that toxic. test sample against 293).Further effectiveness along inflammatory response mice models are be conducted.