BaiCD gene cluster abundance is negatively correlated with Clostridium difficile infection

• DOI: 10.1371/journal.pone.0196977
• Publication Date: 2018-05-08T18:03:28Z
• Authors: Philipp Solbach; Patrick Chhatwal; Sabrina Woltemate; Evelina Tacconelli; Michael Buhl; Markus Gerhard; Christoph K. Thoe...; Maria J. G. T. Ve...; Nathalie Jazmati; Jan Rupp; Michael P. Manns; Oliver Bachmann; Sebastian Suerbaum
• Keywords: Asymptomatic carrier

Clostridium difficile infection (CDI) is a major cause of hospital-acquired diarrhea. Secondary bile acids were shown to confer resistance colonization by C. difficile. 7α-dehydroxylation key step in transformation primary secondary and required genes have been located single acid-inducible (bai) operon scindens as well hiranonis, two sp. recently reported protect against colonization.