PKR modulates abnormal brain signaling in experimental obesity

• DOI: 10.1371/journal.pone.0196983
• Publication Date: 2018-05-24T18:07:15Z
• Authors: Mariko Taga; François Mouton-L...; Malha Sadoune; Sarah Gourmaud; Jenny Norman; Marion Tible; Sylvie Thomasseau; Claire Paquet; James A. R. Nicoll; Delphine Boche; Jacques Hugon
• Keywords: Protein kinase R

Metabolic disorders including obesity and type 2 diabetes are known to be associated with chronic inflammation obvious risk factors for Alzheimer's disease. Recent evidences concerning suggest that the metabolic inflammasome ("metaflammasome") mediates inflammation. The double-stranded RNA-dependent protein kinase (PKR) is a central component of metaflammasome. In wild (WT) PKR-/- mice, blood glucose, insulin lipid levels brain expression phosphorylated components metaflammasome—PKR, JNK, IRS1 IKKbeta—were studied after induction by high fat diet (HFD). results showed significant increased activated metaflammasome proteins in exposed WT mice but changes were not mice. addition, gain weight was observed also HFD. Increased level more accentuated PKR -/- modulation activity could an appropriate therapeutic approach, aimed at reducing abnormal metabolism linked order reduce neurodegeneration.