Estimation of the duration between HIV seroconversion and HIV diagnosis in different population groups in French Guiana: Strategic information to reduce the proportion of undiagnosed infections

• DOI: 10.1371/journal.pone.0199267
• Publication Date: 2018-06-22T17:25:34Z
• Authors: Mathieu Nacher; Antoine Adenis; Florence Huber; Edouard Hallet; Philippe Abboud; Emilie Mosnier; Bastien Bideau; Christian Marty; Aude Lucarelli; Vanessa Morel; François Lacapère; Loïc Epelboin; Pierre Couppié
• Keywords: Seroconversion

Background Given the great efforts put into strategic objective of reducing proportion HIV-infected patients that are undiagnosed, aim present study was to review temporal trends between 1997 and 2016 for median estimates infection duration CD4 count at diagnosis main patient origins in French Guiana. Methods cell HIV sero-conversion square root decline were obtained using a cohort persons UK, fitting random effect (slope intercept) multilevel linear regression models. Multivariate analysis used robust modeling delay estimated seroconversion quantile diagnosis. Results The interval 8 years fromBrazil, 4.5 those from Haiti, 6.6 Suriname, 3.3 Guyana, 3.1 patients. A simple model with as reference group adjusting sex age time showed significantly longer Brazilian (β = +3.7 years, P 0.001), Surinamese +4.2 P<0.0001), Haitian +1.5 0.049) but not originating Guyana -0.03 0.9); Men independently had than women +3.5 P<0.0001). Conclusions Despite Guiana regarding testing both terms diversification intensification we still need tailor offer better reach communities need. These results should help authorities scale up optimize initiatives reduce who unaware their infection. They also raise question role stigma discrimination barrier small communities, further emphasize importance it.