Is infant arterial stiffness associated with maternal blood pressure in pregnancy? Findings from a UK birth cohort (Baby VIP study)

• DOI: 10.1371/journal.pone.0200159
• Publication Date: 2018-07-12T13:53:25Z
• Authors: Ka Ying Bonnie Ng; Nigel A. B. Simpson; Janet E. Cade; Darren C. Greenwood; Harry J. Mcardle; Etienne Ciantar; Nisreen A. Alwan
• Keywords: Adult; Male; Science; 610; Blood Pressure; Gestational Age; Pulse Wave Analysis; 618; Cohort Studies; 03 medical and health sciences; Vascular Stiffness; 0302 clinical medicine; Heart Rate; Predictive Value of Tests; Pregnancy; Risk Factors; Humans; Maternal-Fetal Exchange; Q; R; Infant, Newborn; Infant; United Kingdom; 3. Good health; Cardiovascular Diseases; Prenatal Exposure Delayed Effects; Linear Models; Medicine; Female; Research Article

Background In adults, arterial stiffness measured by pulse wave velocity (PWV) is regarded as a predictor of cardiovascular disease. Infant vascular development depends on factors related to pregnancy, including maternal blood pressure (BP). This study assessed the association between BP in pregnancy and infant brachio-femoral PWV at age 2–6 weeks. Methods The Baby Vascular health Iron Pregnancy (Baby VIP) birth cohort which heart rate (HR) 284 babies Leeds, UK, weeks after birth. Maternal measurements 12 36 gestation was collected from antenatal clinical records. Multivariable linear regression models associations systolic diastolic BPs, change booking weeks, with adjusting for covariables both mother baby level. Results There no evidence an (adjusted coefficient -0.01 m/s per 10mmHg, 95% CI -0.11, 0.14, p = 0.84) or 0.00 -0.12, 0.11, 0.95). Change more than 30 mmHg 15 also not associated PWV. inverse relationship HR (regression -0.14 10 bpm, -0.22, -0.05, p<0.01). Conclusions has shown early late pregnancy. inversely Further studies are required determine predictors well importance long term implications infants.