A prospective matched study on symptomatic dengue in pregnancy

• DOI: 10.1371/journal.pone.0202005
• Publication Date: 2018-10-03T17:41:02Z
• Authors: Célia Basurko; Sibille Everhard; Séverine Matheus; Marion Restrepo; Hélène Hildéral; Véronique Lambert; Rachida Boukhari; Jean-Pierre Duver...; Anne Favre; Larissa Valmy; Mathieu Nacher; Gabriel Carles
• Keywords: Seroconversion

Dengue fever is an increasing problem worldwide, but consequences during pregnancy remain unclear. Much of the available literature suffers from methodological biases that compromise validity clinical recommendations. We conducted a matched cohort study epidemic in French Guiana to compare events and outcomes between two paired groups pregnant women: women having presented with symptomatic dengue (n = 73) had neither nor 219). Women each arm were by place follow up, gestation weeks at inclusion, residence. infection was considered be confirmed if viral RNA, N S1 antigen, seroconversion IgM antibodies or presence detected collected samples. According 2009 WHO classification, 27% least one biological warning sign. These complications occurred after 28th week 55% cases. The medical history, socioeconomic status demographic characteristics included multivariate analysis. Exposure not significantly associated prematurity, small for gestational age infants, hypertension emergency caesarian section. Maternal signs risk factor peripartum hemorrhage adjusted relative 8.6(95% CI 1.2-62). There near significant association utero death (p 0.09). This prospective comparative underlined importance taking into account potential confounders exposure occurrence obstetrical events. It also confirms need increased vigilance dengue, particularly who present severe dengue.