Chronic fatigue syndrome patients have alterations in their oral microbiome composition and function

• DOI: 10.1371/journal.pone.0203503
• Publication Date: 2018-09-11T16:37:09Z
• Authors: Taiwu Wang; Lei Yu; Cong Xu; Keli Pan; Minglu Mo; Mingxiang Duan; Yao Zhang; Hongyan Xiong
• Keywords: Fusobacteria; Fusobacterium; Pathogenesis; Prevotella; Veillonella; Oral Microbiome

Host-microbe interactions have been implicated in the pathogenesis of chronic fatigue syndrome (CFS), but whether oral microbiome is altered CFS patients unknown. We explored alterations Chinese Han using 16S rRNA gene sequencing and functional potential PICRUSt. found that Shannon Simpson diversity indices were not different compared to healthy controls, overall composition was (MANOVA, p < 0.01). had a higher relative abundance Fusobacteria with controls. Further, genera Leptotrichia, Prevotella, Fusobacterium enriched Haemophilus, Veillonella, Porphyromonas depleted Functional analysis from inferred metagenomes showed bacterial primarily associated amino acid energy metabolism. Our findings demonstrate these differences lead shifts pathways implications for pathogenesis. These increase our understanding relationship between microbiota CFS, which will advance may contribute future improvements treatment diagnosis.