Forensic characterization and genetic polymorphisms of 19 X-chromosomal STRs in 1344 Han Chinese individuals and comprehensive population relationship analyses among 20 Chinese groups

• DOI: 10.1371/journal.pone.0204286
• Publication Date: 2018-09-20T18:00:09Z
• Authors: Pengyu Chen; Guanglin He; Xing Zou; Mengge Wang; Fuquan Jia; Huiru Bai; Jida Li; Jian Yu; Yanyan Han
• Keywords: Chinese population; Genetic relationship

X-chromosomal short tandem repeats (X-STRs) may assist resolution of complex forensic kinship cases and complement autosomal Y-chromosomal STRs in routine practice population genetics. In the present study, we investigated allele/haplotype diversity genetic characteristics 19 X- 206 Guizhou Han 1344 Meta-Han Chinese individuals using AGCU X19 PCR amplification system. Population relationships within five groups (1344 individuals), between other reference populations belonging to four language families (5074 as well 15 minorities (3730 individuals) were performed Reynolds’s, Nei’s Fst distances, principal component analysis (PCA), multidimensional scaling (MDS), Structure Neighbor-Joining tree. Mean paternity exclusion chance (MEC) Duos > 0.99999999453588 trios 0.99999999999781, power discrimination (PD) 0.99999999999980 on basis allele frequencies. Consistent high MECs PDs can be observed based both diversities markers haplotype seven linkage (LG). DXS10135 LG1 are most informative polymorphic group. The comprehensive comparisons reveal that is a homogenous has genetically closer relationship with Hmong-Mien-speaking than Tibetan-Burman-speaking Turkic-speaking populations. summary, system highly data from 20 analyzed this study used frequency database X-STRs for casework applications.