Impact of successful treatment with direct-acting antiviral agents on health-related quality of life in chronic hepatitis C patients

• DOI: 10.1371/journal.pone.0205277
• Publication Date: 2018-10-09T18:02:01Z
• Authors: Regina Juanbeltz; Iván Martínez-Baz; Ramón San Miguel; Silvia Goñi-Esarte; Juan Manuel Cabasés; Jesús Castilla
• Keywords: Depression; Hepatitis C

Background Direct-acting antivirals (DAA) have demonstrated high efficacy to achieve sustained virological response (SVR) in chronic hepatitis C patients. We aim assess the change health-related quality of life (HRQoL) among patients successfully treated, and identify predictors this variation. Methods In a prospective observational study, with who started DAA therapy between May 2016 April 2017 completed EQ-5D-5L questionnaire at baseline 12 weeks after end before knowing result. Analysis included all SVR. Results Median scores 206 enrolled were 0.857 utility 70.0 visual analogue scale (VAS). Following SVR, reduction occurred proportion mobility problems (35% vs 24%, p = 0.012), pain/discomfort (60% 42%, p<0.001) anxiety/depression (57% 44%, an increase (+0.053, VAS (+10, p<0.001). Score improvements also observed cirrhotic (+0.048 utility, 0.027; +15 VAS, HIV co-infected (+0.039 0.036; +5 0.002). multivariate analyses, middle age (45–64 years) associated greater improvement moderate-advanced liver fibrosis cirrhosis score. Low values value Conclusions The cure infection has short term positive impact on HRQoL mobility, pain/discomfort, anxiety/depression, Patients poor most beneficed.