Seroprevalence of fourteen human polyomaviruses determined in blood donors

• DOI: 10.1371/journal.pone.0206273
• Publication Date: 2018-10-23T21:39:46Z
• Authors: Sergio Kamminga; Els van der Meijden; Mariet C. W. Felt...; Hans L. Zaaijer
• Keywords: Polyomavirus Infections; Seroprevalence; Merkel cell polyomavirus; JC Virus

The polyomavirus family currently includes thirteen human (HPyV) species. In immunocompromised and elderly persons HPyVs are known to cause disease, such as progressive multifocal leukoencephalopathy (JCPyV), haemorrhagic cystitis nephropathy (BKPyV), Merkel cell carcinoma (MCPyV), trichodysplasia spinulosa (TSPyV). Some recently discovered polyomaviruses of still unknown prevalence pathogenic potential. Because infections persist might be transferred by blood components patients, we studied the seroprevalence fourteen in adult Dutch donors. For most observed was high (60–100%), sometimes slightly increasing or decreasing with age. Seroreactivity increased age for JCPyV, HPyV6 HPyV7 decreased BKPyV TSPyV. identified HPyV12, NJPyV LIPyV showed low overall (~5%) seroreactivity, questioning their tropism. Altogether, HPyV common donors, an average nine per subject.