Atypical and severe manifestations of chikungunya virus infection in French Guiana: A hospital-based study

• DOI: 10.1371/journal.pone.0207406
• Publication Date: 2018-12-06T22:21:52Z
• Authors: Timothee Bonifay; Christelle Prince; Clarisse Neyra; Magalie Demar; Dominique Rousset; Hatem Kallel; Mathieu Nacher; Félix Djossou; Loïc Epelboin
• Keywords: Case fatality rate; myalgia

French Guiana (FG) was the first country in South America to declare chikungunya virus infection (CHIKV). The outbreak affected about 16,000 persons between February 2014 and October 2015, with several atypical cases, but only two fatal cases. We aimed describe clinical presentation of patients hospitalized for CHIKV infection, estimate identify risk factors unusual severe forms adult patients.A monocentric retrospective study conducted Cayenne hospital, main city hospital FG, from March 1st August 31st 2015. All admitted at least one night a biological diagnosis during 2014/2015 were included, except pregnant women children under 15 years.During period, 285 among whom 96 nonpregnant adults studied. Five classified as (5.2%) 23 (23.9%). most frequent and/or form neurological (n = 20), followed by cardio-respiratory failure (acute respiratory n 4, acute heart 2), digestive hepatic disorders hepatitis 3, pancreatitis renal 5) muscular impairment (rhabdomyolysis 3).During outbreak, hospitalizations frequent, particularly common forms, driven algic presentations concerns due novelty this infection. Despite liver case-fatality low Guiana. No specific factor found our study.