Quantitative analysis of pupillometry in isolated third nerve palsy

• DOI: 10.1371/journal.pone.0208259
• Publication Date: 2018-11-29T13:53:49Z
• Authors: Hyeong Min Kim; Hee Kyung Yang; Jeong-Min Hwang
• Keywords: Pupillometry

To objectively assess pupillary involvement according to various etiologies of acquired isolated third nerve palsy using automated pupillometry, and evaluate the efficacy digital pupillometry in discriminating compressive lesions from microvascular ischemic palsy.Retrospective, observational case series.A total 171 subjects were included this study, consisting 60 with presumed palsy, 51 non-ischemic controls whose light responses measured a dynamic pupillometer. Subjects divided into subgroups their etiology; inflammatory groups including tumor aneurysm. Pupillometry parameters minimum maximum pupil diameters, constriction latency ratio, average velocities dilation velocity noted. The diagnostic ability for vs was evaluated. inter-eye difference involved eye uninvolved fellow calculated adjust individual variability.Among all parameters, reduced ratio most specific parameter detecting as large beyond normative range found 0% ischemic, 20% 60% palsy. With criteria differences 1) diameter > 0.45 mm, or 2) < -7.5% compared eye, sensitivity specificity diagnosing 95% 88%, respectively. In group, positive correlations between degree external ophthalmoplegia (r = 0.615, p<0.001), 0.591, p 0.001) 0.582, 0.001).Abnormal highly although not high. Digital demonstrated relatively good performance