Response to anti-tuberculosis treatment by people over age 60 in Kampala, Uganda

• DOI: 10.1371/journal.pone.0208390
• Publication Date: 2018-12-19T18:29:33Z
• Authors: Nicholas Sebuliba...; Derrick Kimuli; Seyoum DeJene; Carol Nanziri; Estella Birabwa; Daniel Ayen Okello; Pedro Guillermo S...; Samuel Kasozi; Raymond Byaruhanga; Deus Lukoye
• Keywords: Aged, 80 and over; Male; Science; Q; R; Antitubercular Agents; 1. No poverty; Middle Aged; 3. Good health; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Tuberculosis, Multidrug-Resistant; Medicine; Humans; Female; Uganda; Tuberculosis, Pulmonary; Research Article; Aged; Retrospective Studies

While old age is a known risk factor for developing active tuberculosis (TB), studies on TB in the population aged 60 years and older (considered elderly this study) are few, especially world. Results of prevalence survey Uganda found high (570/100,000) people over 65. We focused treatment outcomes to understand epidemic better. conducted retrospective analysis data from facility registers Kampala City period 2014-2015. analyzed 2014-15 cohort with respect age, sex, disease class, patients' human immunodeficiency virus (HIV) directly observed therapy (DOT) status, type facility, compared findings (≥60) younger (<60) groups. Of 15,429 records, 3.3% (514/15,429) were patients. The success rate (TSR) among patients (68.3%) was lower than that non-elderly (80.9%) overall TSR 80.5%, (12,417/15,429) Kampala. Although less likely test positive HIV young (AOR 0.39; 95% CI 0.33-0.48, p<0.001), they had two-fold higher unfavorable 2.14; 1.84-2.72, p<0.001) more die while 1.86; 1.27-2.73; p = 0.001). However, there no statistically significantly difference between HIV-positive HIV-negative Compared patients, have markedly poorer outcomes, although TB/HIV co-infection rates group lower.