Novel anti-biofouling bioactive calcium silicate-based cement containing 2-methacryloyloxyethyl phosphorylcholine

• DOI: 10.1371/journal.pone.0211007
• Publication Date: 2019-01-17T18:43:41Z
• Authors: Jae-Sung Kwon; Myung-Jin Lee; Ji-Young Kim; Dohyun Kim; Jeong-Hyun Ryu; Sungil Jang; Kwang-Mahn Kim; Chung-Ju Hwang; Sung-Hwan Choi
• Keywords: Calcium silicate; Enterococcus faecalis; Phosphorylcholine

Calcium silicate-based cements (CSCs) are commonly used for endodontic procedures; however, their antibacterial effects limited. The objective of this study was to develop a 2-methacryloyloxyethyl phosphorylcholine (MPC)-incorporated CSC with improved properties, while maintaining the original advantageous features CSC. MPC incorporated into commercial (Endocem MTA) at 0 wt% (control), 1.5%, 3.0 wt%, 5.0 7.5 and 10 wt%. setting time, compressive strength, water sorption, glycerol contact angle were measured. Protein absorption measured bacterial adhesion on surface evaluated using Enterococcus faecalis. bactericidal effect examined by disc diffusion test. Mineralization ability assessed based calcium ion deposition, as alizarin red staining, after immersion Hank's balanced salt solution 7 days. High concentrations in (7.5 wt%) increased reduced wettability. (3 had greater protein repellent anti-biofouling than those control test materials (P < 0.001). However, no observed any or materials. There deposition MPC-supplemented addition 3 polymer confers protein-repellent properties attachment, potential mineralization.