Association between physical activity and change in renal function in patients after acute myocardial infarction

• DOI: 10.1371/journal.pone.0212100
• Publication Date: 2019-02-19T18:56:25Z
• Authors: Toshimi Sato; Masahiro Kohzuki; Masahiro Ono; Mitsuru Muto; Taku Osugi; Keiichi Kawamura; Wakako Naganuma; Masayuki Sato; Namiko Shishito
• Keywords: Male; Science; Q; R; Myocardial Infarction; Middle Aged; Kidney; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Acute Disease; Medicine; Humans; Female; Cystatin C; Exercise; Research Article; Aged; Glomerular Filtration Rate

Combined renal dysfunction worsens the subsequent prognosis in patients after acute myocardial infarction (AMI). Therefore, establishing a therapeutic modality to maintain or improve function AMI is necessary. This study aimed elucidate association between physical activity level and change such patients.Prospective observational study.We enrolled 41 (35 men; average age, 67.5 ± 12.6 years) onset. Blood biochemistry, urinalysis, tests were conducted at discharge 3 months discharge. Renal was evaluated based on cystatin C based-estimated glomerular filtration rate (eGFRcys). The number of steps recorded for post-discharge. Generalized estimating equations (GEE) used test within-patient changes eGFRcys.Patients stratified into low (n = 21; steps, 2335 1219 steps/day) high groups 20; 7102 2365 steps/day). eGFRcys significantly increased from baseline group (76.5 13.8 83.2 16.0 mL/min/1.73 m2, q 0.004), whereas no significant observed (65.1 15.9 62.2 20.2 0.125). Result GEE adjusted potential confounding variables showed positive (p 0.003). Changes -2.9 m2 among versus +6.7 group.Physical positively associated with function, demonstrating that may suppress decline AMI.