Contribution of lower physical activity levels to higher risk of insulin resistance and associated metabolic disturbances in South Asians compared to Europeans

• DOI: 10.1371/journal.pone.0216354
• Publication Date: 2019-05-07T18:50:58Z
• Authors: Saima Afaq; Angad S. Kooner; Marie Loh; Jaspal S. Kooner; John C. Chambers
• Keywords: Metabolic equivalent

Background Insulin resistance and related metabolic disturbances are major risk factors for the higher T2D associated morbidity mortality amongst South Asians. The contribution of physical activity to increased prevalence insulin Asians is unknown. Methods We recruited 902 Asian European men women, aged 35–85 years from ongoing LOLIPOP study. Clinical characterisation comprised standardised questionnaire measurement height, weight, waist hip circumference blood pressure. Fasting bloods were taken assessment glucose, insulin, lipids HbA1c. Physical was quantified using a validated accelerometer, Actigraph GT3X+, worn 7 days. Univariate multivariate approaches used investigate relationship between ethnicity, activity, disturbances. Results Total ~31% (P = 0.01) lower compared Europeans (Mean MET.minutes [SD]: 1505.2 [52] vs. 2050.9 [86.6], P<0.001). After adjusting age sex, total had negative association with HOMA-IR (B [SE]: -0.18 [0.08], P 0.04) fasting glucose levels (B[SE]: -0.11 [0.04], 0.02). There no other glycemic lipid parameters. per week contributed towards differences in Europeans. Conclusion Lower may contribute Our results suggest that lifestyle modification through help improve metabolism reduce burden excess complications